Look at the date before you take a clozaril and every six months.
Information about Clozaril.
Rare but serious reports of seizuresincluding onset of seizures in non-epileptic patientsand isolated cases of delirium where Clozaril was co-administered with valproic acid have been reportedThese effects are possibly due to a pharmacodynamic interactionthe mechanism of which has not been determined.
Substances known to have a substantial potential to depress bone marrow function must not be used concurrently with Clozarilsee section 4.3
Clozapine may cause a condition that affects the heart rhythmQT prolongationQT prolongation can rarely cause seriousrarely fatalfast/irregular heartbeat and other symptomssuch as severe dizzinessfaintingthat need medical attention right away.
Prescribers and pharmacists should adhere to brand prescribing and dispensing of clozapine in order to prevent the disruption to effective monitoring that may be caused if patients switch brands.
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risperidone will also continue to be targeted for comparative-and competitive-assessments, since it was the first antipsychotic, after the more toxic clozapine clozaril , to successfully depart from the pharmacology of conventional neuroleptics.