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Studies in man indicate that the peak concentration in the aqueous humour is reached about two hours after topical administrationAfter topical application in monkeyslatanoprost is distributed primarily in the anterior segmentthe conjunctivae and the eyelidsOnly minute quantities of the drug reach the posterior segment.
Iris pigmentation changessee WARNINGS AND PRECAUTIONSEyelid skin darkeningsee WARNINGS AND PRECAUTIONSEyelash changesincreased lengththicknesspigmentationand number of lashessee WARNINGS AND PRECAUTIONSIntraocular inflammationiritis/uveitissee WARNINGS AND PRECAUTIONSMacular edemaincluding cystoid macular edemasee WARNINGS AND PRECAUTIONS
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