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It is not known whether sucralfate passes into breast milk or if it could harm a nursing babyTell your doctor if you are breast-feeding a baby.
Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorptionbioavailabilityof single doses of the followingcimetidinedigoxinfluoroquinolone antibioticsketoconazolel-thyroxinephenytoinquinidineranitidinetetracyclineand theophyllineSubtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reportsHowevertwo clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapyThe mechanism of these interactions appears to be nonsystemic in naturepresumably resulting from sucralfate binding to the concomitant agent in the gastrointestinal tractIn all cases studied to datecimetidineciprofloxacindigoxinnorfloxacinofloxacinand ranitidinedosing the concomitant medication 2 hours before sucralfate eliminated the interactionDue to CARAFATE Oral Suspension’s potential to alter the absorption of some drugsCARAFATE Oral Suspension should be administered separately from other drugs when alterations in bioavailability are felt to be criticalIn these casespatients should be monitored appropriately.
Get emergency medical help if you have any of these signs of an allergic reaction to Carafatehivesdifficult breathingswelling of your facelipstongueor throat.
Studies in human subjects and with animal models of ulcer disease have shown that sucralfate forms an ulcer-adherent complex with proteinaceous exudate at the ulcer siteIn vitroa sucralfate-albumin film provides a barrier to diffusion of hydrogen ionsIn human subjectssucralfate given in doses recommended for ulcer therapy inhibits pepsin activity in gastric juice by 32
Antacids may be prescribed as needed for relief of pain but should not be taken within one-half hour before or after CARAFATE Oral Suspension.
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