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Although this effect represents a pharmacodynamic interaction, dosage adjustments of probenecid may be necessary if triamterene is administered to patients being treated with probenecid.
Information about Triamterene.
Studies of the effects of MAXZIDEthe triamterene/hydrochlorothiazide combinationor of triamterene alone on animal reproductive function have not been conducted.
If hyperkalemia is suspectedwarning signs include paresthesiasmuscular weaknessfatigueflaccid paralysis of the extremitiesbradycardia and shockan electrocardiogramECGshould be obtainedHoweverit is important to monitor serum potassium levels because mild hyperkalemia may not be associated with ECG changes.
Triamterene is a potassium-conservingantikaliureticdiuretic with relatively weak natriuretic propertiesIt exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogenWith this actiontriamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazideTriamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison’s diseasei.ewithout aldosteroneTriamterene’s onset and duration of activity is similar to hydrochlorothiazideNo predictable antihypertensive effect has been demonstrated with triamterene.
MAXZIDE may be used alone or in combination with other antihypertensive drugssuch as beta-blockersSince MAXZIDEtriamterene and hydrochlorothiazidemay enhance the actions of these drugsdosage adjustments may be necessary.
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lab tests, including blood electrolytes, blood cell counts, kidney and liver function tests, blood uric acid levels, and blood pressure, may be performed while you use triamterene.
