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The first 18 weeks of therapy with viramune xr are a critical period during which intensive clinical and laboratory monitoring of patients is required to detect potentially life-threatening hepatic events.
Information about Viramune.
The limited data available with saquinavir soft gel capsule boosted with ritonavir do not suggest any clinically relevant interaction between saquinavir boosted with ritonavir and nevirapine.
The available pharmacokinetic data suggest that the concomitant use of rifampicin and nevirapine is not recommendedFurthermorecombining the following compounds with Viramune is not recommendedefavirenzketoconazoledelavirdineetravirinerilpivirineelvitegravirin combination with cobicistatatazanavirin combination with ritonavirboceprevirfosamprenavirif not co-administered with low dose ritonavirsee section 4.5
Rhabdomyolysis has been observed in patients experiencing skin and/or liver reactions associated with Viramune use.
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in this open-label trial, 443 subjects already on an antiviral regimen containing immediate-release viramune 200 mg twice daily with hiv-1 rna less than 50 copies per ml were randomized in a 2 1 ratio to viramune xr 400 mg once daily or immediate-release viramune 200 mg twice daily.
