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Patients with a history of a clinically significant low wbc or a drug-induced leukopenia neutropenia should have their complete blood count cbc monitored frequently during the first few months of therapy and discontinuation of haldol decanoate should be considered at the first sign of a clinically significant decline in wbc in the absence of other causative factors.

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In generalthe symptoms of overdosage would be an exaggeration of known pharmacologic effects and adverse reactionsthe most prominent of which would be1severe extrapyramidal reactions2hypotensionor 3sedationThe patient would appear comatose with respiratory depression and hypotension which could be severe enough to produce a shock-like stateThe extrapyramidal reactions would be manifested by muscular weakness or rigidity and a generalized or localized tremor as demonstrated by the akinetic or agitans types respectivelyWith accidental overdosagehypertension rather than hypotension occurred in a two-year old childThe risk of ECG changes associated with torsade de pointes should be consideredFor further information regarding torsade de pointesplease refer to ADVERSE REACTIONS

Although not reported with HALDOLdecreased serum cholesterol and/or cutaneous and ocular changes have been reported in patients receiving chemically-related drugs.

Antipsychotic drugs elevate prolactin levelsthe elevation persists during chronic administrationTissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitroa factor of potential importance if the prescription of these drugs is contemplated in a patient with a previously detected breast cancerAlthough disturbances such as galactorrheaamenorrheagynecomastiaand impotence have been reportedthe clinical significance of elevated serum prolactin levels is unknown for most patientsAn increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugsNeither clinical studies nor epidemiologic studies conducted to datehoweverhave shown an association between chronic administration of these drugs and mammary tumorigenesisthe available evidence is considered too limited to be conclusive at this time.

Haloperidol is not for use in psychotic conditions related to dementiaHaloperidol may cause heart failuresudden deathor pneumonia in older adults with dementia-related conditions.

Haloperidol can also be used to treat uncontrolled movements and outbursts of words/sounds related to Tourette’s disorderHaloperidol is also used for severe behavior problems in hyperactive children when other treatments or medications have not worked.

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