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Theophylline has two distinct actions in the airways of patients with reversible obstructionsmooth muscle relaxationi.ebronchodilationand suppression of the response of the airways to stimulii.enon-bronchodilator prophylactic effectsWhile the mechanisms of action of theophylline are not known with certaintystudies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterasePDE III andto a lesser extentPDE IVwhile non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanismsthat do not involve inhibition of PDE III or antagonism of adenosine receptorsSome of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE IIIe.ghypotensiontachycardiaheadacheand emesisand adenosine receptor antagonisme.galterations in cerebral blood flow
Store the medicine in a closed container at room temperatureaway from heatmoistureand direct lightKeep from freezing.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of theophylline in childrenHoweverchildren younger than 1 year of age are more likely to have serious side effectswhich may require caution and an adjustment in the dose for patients receiving theophylline.
Selected from data included with permission and copyrighted by First DatabankIncThis copyrighted material has been downloaded from a licensed data provider and is not for distributionexpect as may be authorized by the applicable terms of use.
You are allergic to any ingredient in Quibron-Tsimilar medicinesegaminophyllineor xanthinesegcaffeinechocolateyou are using large amounts of other products that contain xanthinesuch as chocolate or caffeinated drinksyou are taking dipyridamole intravenouslyIVfebuxostathalothaneor StJohn’s wort.
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