There is no clinically significant effect of food on the bioavailability of hydrochlorothiazide.

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Skeletal muscle relaxantsnondepolarizinge.gtubocurarinepossible increased responsiveness to the muscle relaxant.
Thiazides are excreted in breast milkBecause of the potential for serious adverse reactions in nursing infantsa decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazidetaking into account the importance of the drug to the mother.
Lithiumgenerally should not be given with diureticsDiuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicityRefer to the package insert for lithium preparations before use of such preparations with MICROZIDEhydrochlorothiazide capsule
Avoid becoming overheated or dehydrated during exercisein hot weatheror by not drinking enough fluidsFollow your doctor’s instructions about the type and amount of liquids you should drinkIn some casesdrinking too much liquid can be as unsafe as not drinking enough.
HypersensitivityAnaphylactic reactionsnecrotizing angiitisvasculitis and cutaneous vasculitisrespiratory distress including pneumonitis and pulmonary edemaphotosensitivityfeverurticariarashpurpura.
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therefore, when zebeta fumarate and hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.