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Limited pharmacokinetic data suggest that a lumbar-cisternal concentration gradient of about 4:1 is established along the neuroaxis during baclofen infusionThis is based upon simultaneous CSF sampling via cisternal and lumbar tap in 5 patients receiving continuous baclofen infusion at the lumbar level at doses associated with therapeutic efficacythe interpatient variability was greatThe gradient was not altered by position.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofkidney diseasemental/mood disorderssuch as schizophreniabrain disorderssuch as seizuresstroke

Pharmacokinetics of LIORESAL INTRATHECALThe pharmacokinetics of CSF clearance of LIORESAL INTRATHECAL calculated from intrathecal bolus or continuous infusion studies approximates CSF turnoversuggesting elimination is by bulk-flow removal of CSF.

During pregnancythis medication should be used only when clearly neededDiscuss the risks and benefits with your doctor.

PEDIATRIC USE Children should be of sufficient body mass to accommodate the implantable pump for chronic infusionPlease consult pump manufacturer’s manual for specific recommendations.

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