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Procardia is indicated for the management of chronic stable anginaeffort-associated anginawithout evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or organic nitrates or who cannot tolerate those agents.
Mild to moderate peripheral edematypically associated with arterial vasodilation and not due to left ventricular dysfunctionoccurs in about one in ten patients treated with ProcardianifedipineThis edema occurs primarily in the lower extremities and usually responds to diuretic therapyWith patients whose angina is complicated by congestive heart failurecare should be taken to differentiate this peripheral edema from the effects of increasing left ventricular dysfunction.
Althoughlike other members of its classProcardia decreases sinoatrial node function and atrioventricular conduction in isolated myocardial preparationssuch effects have not been seen in studies in intact animals or in manIn formal electrophysiologic studiespredominantly in patients with normal conduction systemsProcardia has had no tendency to prolong atrioventricular conductionprolong sinus node recovery timeor slow sinus rate.
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although patients have rarely experienced excessive hypotension on procardia alone, this may be more common in patients on concomitant beta blocker therapy.
