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It is not known whether promethazine is harmful to an unborn baby.
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Slowed breathing Fast or irregular pulse or heartbeat Abnormal or uncontrollable movements Hallucinationsseeing things or hearing voices that do not existConfusion Overwhelming or unmanageable fear or emotion Seizures Unusual bruising or bleeding Uncontrolled eye movements.
CNS DepressantsPromethazine hydrochloride tablets may increaseprolongor intensify the sedative action of other central-nervous-system depressantssuch as alcoholsedatives/hypnoticsincluding barbituratesnarcoticsnarcotic analgesicsgeneral anestheticstricyclic anti-depressantsand tranquilizersthereforesuch agents should be avoided or administered in reduced dosage to patients receiving promethazine HClWhen given concomitantly with promethazine hydrochloride tabletsthe dose of barbiturates should be reduced by at least one-halfand the dose of narcotics should be reduced by one-quarter to one-halfDosage must be individualizedExcessive amounts of promethazine HClpromethazine hydrochloriderelative to a narcotic may lead to restlessness and motor hyperactivity in the patient with painthese symptoms usually disappear with adequate control of the pain.
Older adults may be more sensitive to the side effects of this drugespecially drowsinessconfusionconstipationor trouble urinatingDrowsiness and confusion can increase the risk of falling.
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