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Danazol is a synthetic androgen1Androgens are hormones produced by the male testesThey are responsible for the functioning of the male reproductive system and the development of the male characteristicssuch as facial hair and a deep voiceThe ovaries also produce small amounts of androgens.
5Severe symptomatic gynaecomastiaboth idiopathic as well as drug inducedto reduce the size of the breast and to control associated pain and tenderness.
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Since hepatic dysfunction manifested by modest increases in serum transaminase levels has been reported in patients treated with Danazolperiodic liver function tests should be performedsee WARNINGS and ADVERSE REACTIONS
A temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during Danazol therapyThese alterations may be markedand prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.
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