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Do not swallow the tablet wholeAllow it to dissolve in your mouth without chewingIf desiredyou may drink liquid to help swallow the dissolved tablet.
If rizatriptan is administered according to the maximum dosage regimenno drug accumulation in the plasma occurs from day to day.
Preclinical data indicate no risk for humans based on conventional studies of repeat dose toxicitygenotoxicitycarcinogenic potentialreproductive and developmental toxicitysafety pharmacologyand pharmacokinetics and metabolism.
Thereforecaution should be exercised when administering rizatriptan to women who are breast-feedingInfant exposure should be minimised by avoiding breast-feeding for 24 hours after treatment.
Angioedemae.gfacial oedematongue swelling and pharyngeal oedemamay occur in patients treated with triptansamong which is rizatriptanIf angioedema of the tongue or pharynx occursthe patient should be placed under medical supervision until symptoms have resolvedTreatment should promptly be discontinued and replaced by an agent belonging to another class of drugs.
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