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After taking this medicine for long periods of timesuch as a year or moresome people suddenly lose the ability to moveThis loss of movement may last from a few minutes to several hoursThe person is then able to move as beforeThis condition may unexpectedly occur again and againThis problem is called theon-offeffectYour doctor may prescribe you a stronger dose of SINEMET or may ask you to take it more frequentlyYour doctor may need to prescribe you a different medicine.
Tell your doctor if you are taking any other medicinesincluding any that you buy without a prescription from your pharmacysupermarket or health food shopSome medicines and SINEMET may interfere with each otherThese include:
There are no adequate or well-controlled studies in pregnant womenIt has been reported from individual cases that levodopa crosses the human placental barrierenters the fetusand is metabolizedCarbidopa concentrations in fetal tissue appeared to be minimalUse of SINEMET in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child.
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long-term administration of sinemet retard requires placement of a peg-j outer transabdominal tube and inner jejunal tube by percutaneous endoscopic gastrostomy.
